A Case of Relapsing Granulomatosis with Polyangiitis Treated Successfully with Rituximab.
10.4078/jrd.2014.21.5.257
- Author:
Ji Won HAN
1
;
Kwi Young KANG
;
Tae Hyun BAN
;
Ik Hyun JO
;
Sung Hwan PARK
Author Information
1. Division of Rheumatology, Department of Internal Medicine, Catholic University of Korea, College of Medicine, Seoul, Korea. kykang@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Granulomatosis with polyangiitis;
Cranial nerve;
Rituximab
- MeSH:
Antibodies, Antineutrophil Cytoplasmic;
Cranial Nerve Diseases;
Cranial Nerves;
Cyclophosphamide;
Glucocorticoids;
Granuloma;
Humans;
Kidney;
Lung;
Male;
Middle Aged;
Neurologic Manifestations;
Vasculitis;
Rituximab
- From:Journal of Rheumatic Diseases
2014;21(5):257-260
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Granulomatosis with polyangiitis (GPA) is a rare antineutrophil cytoplasmic antibody associated with systemic disease characterized by granulomas and vasculitis affecting small and medium vessels. Neurological manifestations in GPA are less frequent than classical manifestations, such as lung and kidney involvement, and cranial nerve palsies are much rarer. Cyclophosphamide and glucocorticoids have been conventionally administered as an initial induction immunosuppressive therapy for GPA. However, increasing evidence has demonstrated the efficacy and safety of rituximab, an anti-B cell monoclonal antibody, for the treatment of GPA. Herein, we describe a successful treatment of relapsing GPA with cranial nerve involvement using rituximab in a 56-year-old male patient who was previously treated with cyclophosphamide plus glucocorticoids.