Tomographic and histometric analysis of autogenous bone block and synthetic hydroxyapatite block grafts without rigid fixation on rabbit calvaria.
10.5051/jpis.2014.44.5.251
- Author:
Soo Yong BAE
1
;
Jung Chul PARK
;
Hyun Seung SHIN
;
Yong Keun LEE
;
Seong Ho CHOI
;
Ui Won JUNG
Author Information
1. Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea. drjew@yuhs.ac
- Publication Type:Original Article
- Keywords:
Animal experiments;
Bone regeneration;
Hydroxyapatites
- MeSH:
Animal Experimentation;
Animals;
Bone Regeneration;
Bone Resorption;
Dislocations;
Durapatite*;
Hydroxyapatites;
Osteogenesis;
Skull*;
Transplants*;
X-Ray Microtomography
- From:Journal of Periodontal & Implant Science
2014;44(5):251-258
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The preferred material for bone augmentation beyond the envelope of skeletal bone is the bone block graft, due to its dimensional stability. We evaluated the necessity of rigid fixation for the bone block graft, and compared the bone regeneration and volume maintenance associated with grafting using a synthetic hydroxyapatite block (HAB) and an autogenous bone block (ABB) without rigid fixation on rabbit calvaria over two different periods. METHODS: Cylinder-shaped synthetic HAB and ABB were positioned without fixation on the rabbit calvarium (n=16). The animals were sacrificed at 4 or 8 weeks postoperatively, and the grafted materials were analyzed at each healing period using microcomputed tomography and histologic evaluation. RESULTS: Integration of the graft and the recipient bed was observed in all specimens, although minor dislocation of the graft materials from the original position was evident in some specimens (six ABB and ten HAB samples). A tendency toward progressive bone resorption was observed in the grafted ABB but not in the grafted HAB, which maintained an intact appearance. In the HAB group, the area of new bone increased between 4 and 8 weeks postoperatively, but the difference was not statistically significant. CONCLUSIONS: The nonfixed HAB was successfully integrated into the recipient bed after both healing periods in the rabbit calvaria. In spite of limited bone formation activity in comparison to ABB, HAB may be a favorable substitute osteoconductive bone material.
