Late Respiratory Infection after Lung Transplantation.
- Author:
Sang Young KIM
1
;
Jung Ar SHIN
;
Eun Na CHO
;
Min Kwang BYUN
;
Hyung Jung KIM
;
Chul Min AHN
;
Suk Jin HAAM
;
Doo Yun LEE
;
Hyo Chae PAIK
;
Yoon Soo CHANG
Author Information
- Publication Type:Original Article
- Keywords: Lung Transplantation; Respiratory Tract Infections
- MeSH: Acinetobacter baumannii; Bacteria; Bacterial Infections; beta-Lactamases; Colon; Humans; Klebsiella pneumoniae; Lung; Lung Transplantation; Methicillin-Resistant Staphylococcus aureus; Pneumonia; Pseudomonas aeruginosa; Respiratory Tract Infections; Risk Factors; Streptococcus pneumoniae; Tissue Donors
- From:Tuberculosis and Respiratory Diseases 2013;74(2):63-69
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Aiming to improve outcome of lung transplantation (LTx) patients, we reviewed risk factors and treatment practices for the LTx recipients who experienced respiratory infection in the late post-LTx period (>1 month after LTx). METHODS: We analyzed the clinical data of 48 recipients and donors from 61 LTx, who experienced late respiratory infections. Late respiratory infections were classified according to the etiology, time of occurrence, and frequency of donor-to-host transmission or colonization of the recipient prior to transplantation. RESULTS: During the period of observation, 42 episodes of respiratory infections occurred. The organisms most frequently involved were gram (-) bacteria: Acinetobacter baumannii (n=13, 31.0%), Pseudomonas aeruginosa (n=7, 16.7%), and Klebsiella pneumoniae (n=4, 10.0%). Among the 42 episodes recorded, 14 occurred in the late post-LTx period. These were bacterial (n=6, 42.9%), fungal (n=2, 14.3%), viral (n=4, 28.5%), and mycobacterial (n=2, 14.3%) infections. Of 6 bacterial infections, 2 were from multidrug-resistant (MDR) A. baumannii and one from each of MDR P. aeruginosa, extended spectrum beta-lactamase (+) K. pneumoniae, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae. Infection-related death occurred in 6 of the 14 episodes (43%). CONCLUSION: Although the frequency of respiratory infection decreased sharply in the late post-LTx period, respiratory infection was still a major cause of mortality. Gram (-) MDR bacteria were the agents most commonly identified in these infections.
