A standardized bamboo leaf extract inhibits monocyte adhesion to endothelial cells by modulating vascular cell adhesion protein-1.
- Author:
Sunga CHOI
1
;
Myoung Soo PARK
;
Yu Ran LEE
;
Young Chul LEE
;
Tae Woo KIM
;
Seon Gil DO
;
Dong Seon KIM
;
Byeong Hwa JEON
Author Information
- Publication Type:Original Article
- Keywords: Bamboo leaf extracts; anti-inflammation; reactive oxygen species; interleukin-6; endothelial cells
- MeSH: Asia; Atherosclerosis; Cardiovascular Diseases; Cell Adhesion; Cell Survival; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Interleukin-6; Japan; Korea; Medicine, Traditional; Monocytes; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1
- From:Nutrition Research and Practice 2013;7(1):9-14
- CountryRepublic of Korea
- Language:English
- Abstract: Bamboo leaves (Phyllostachys pubescens Mazel ex J. Houz (Poacea)) have a long history of food and medical applications in Asia, including Japan and Korea. They have been used as a traditional medicine for centuries. We investigated the mechanism of anti-inflammatory activity of a bamboo leaf extract (BLE) on tumor necrosis factor-alpha (TNF-alpha)-induced monocyte adhesion in human umbilical vein endothelial cells (HUVECs). Exposure of HUVECs to BLE did not inhibit cell viability or cause morphological changes at concentrations ranging from 1 microg/ml to 1 mg/ml. Treatment with 0.1 mg/ml BLE caused 63% inhibition of monocyte adhesion in TNF-alpha-activated HUVECs, which was associated with 38.4% suppression of vascular cell adhesion molecule-1 expression. Furthermore, TNF-alpha-induced reactive oxygen species generation was decreased to 47.9% in BLE treated TNF-alpha-activated HUVECs. BLE (0.05 mg/ml) also caused about 50% inhibition of interleukin-6 secretion from lipopolysaccharide-stimulated monocyte. The results indicate that BLE may be clinically useful as an anti-inflammatory or anti-oxidant for human cardiovascular disease including atherosclerosis.
