Urea Synthesis in the Intact and in the Isolated Perfused Liver of the Biotin-Deficient Rats.
- Author:
Je Hyun KIM
1
;
Moo Youn CHO
;
Byung Woo KIM
;
Chug Suk SONG
Author Information
- Publication Type:Original Article
- MeSH: Animal; Avitaminosis/metabolism; Biotin*; Liver/metabolism*; Rats; Urea/biosynthesis*; MH -; Substances:; Urea; Biotin
- From:Yonsei Medical Journal 1971;12(1):13-16
- CountryRepublic of Korea
- Language:English
- Abstract: Biotin-deficient rats were raised on a purified ration containing raw egg white plus avidin. Urea synthesis and excretion were compared between the biotin-deficient and the pair-fed control rats. 24hrurinary urea excretion and the specific activities of carbamylphosphate synthetase, ornithine transcarbamylase, and arginase in the liver mitochondria fraction were no different between these two groups. The net urea production in the liver slice and in the isolated perfused liver of the biotin-deficient rats was similar to that of the pair-fed control. Thus the conclusion must be that biotin is not in urea in mea biosynthesis in the rat.
