Comparative study on the Effects of Platelet-Rich Plasma and Enamel Matrix Protein on Supracrestal bone Regeneration of Dental Implant.
10.5051/jkape.2005.35.1.235
- Author:
Hee Jong EUN
1
;
Sung Bin LIM
;
Chin Hyung CHUNG
;
Ki Seok HONG
;
Chong Heon LEE
Author Information
1. Department of Periodontology, College of Dentistry, Dan-Kook University, Korea. periodk@dankook.ac.kr
- Publication Type:Comparative Study ; Original Article
- Keywords:
Platelet-Rich Plasma;
Enamel Matrix Protein;
bone regeneration
- MeSH:
Bone Density;
Bone Regeneration*;
Bone Remodeling;
Dental Enamel*;
Dental Implants*;
Femur;
Heterografts;
Intercellular Signaling Peptides and Proteins;
Osseointegration;
Osteogenesis;
Platelet-Rich Plasma*;
Regeneration;
Staphylococcal Protein A;
Transplants
- From:The Journal of the Korean Academy of Periodontology
2005;35(1):235-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The current interest in periodontal tissue regeneration has lead to research in bone graft, root surface treatments, guided-tissue regeneration, administration of growth factors, and the use of enamel matrix protein as possible means of regenerating lost periodontal tissue. Several studies have shown that a strong correlation between platelet-rich plasma and the stimulation of remodeling and remineralization of grafted bone exits, resulting in a possible increase of 15-30% in the density of bone trabeculae. The purpose of this study was to study the histopathological results and differences between the use of platelet-rich plasma and the use of enamel matrix protein(Emdogain?) about bone regeneration at the implant. Implant fixtures were inserted and graft materials placed into the left femur in the experimental group, while the only implant fixtures placed in the control group. In the first experimental group, platelet-rich plasma and xenograft were placed at the supracrestally placed implant site, and in the second experimental group, Emdogain(R) and xenograft placed at the supracrestally placed fixture site. The degree of bone regeneration adjacent to the implant fixture was observed and compared histopathologically at 2, 4, and 8 weeks after implant fixture insertion. The results of the experiment are as follows: 1. The rate of osseointegration to the fixture threads was found to be greater in the experimental group compared to in the control group. 2. The histopathological findings showed that the bone regeneration, the partial osseointegration existed at 4 weeks, and that osseointegration and bone density increaced in the experimental groups at 8 weeks. 3. The results showed that new bone formation and bone remodeling increased in the area near to the fixture in the first and second experimental groups at 8 weeks than at 4 weeks. The results showed that in the area distant from the fixture, new bone formation did not increase and bone remodeling decreased in the first experimental group at 4, 8 weeks, and that new bone formation increased in the second experimental group. 4. The histopathological findings showed that AZ deposition in the first experimental group was remarkable at 2, 8 weeks, and in the second experimental group at 2, 4, 8 weeks in the area distant from the fixture threads.
