Cytologic Features and BRAF Mutation of Hyalinizing Trabecular Adenoma of the Thyroid: A Case Report with Review of the Literature.
- Author:
Se Min JANG
1
;
Young Ha OH
;
Yoon Kyung JEON
;
Yong Wook PARK
;
Moon Hyang PARK
Author Information
1. Department of Pathology, Hanyang University College of Medicine, Seoul, Korea. yhoh@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Adenoma;
Cytology;
BRAF;
Thyroid
- MeSH:
Adenoma;
Carcinoma, Medullary;
Epithelial Cells;
Female;
Humans;
Hyalin;
Middle Aged;
Thyroid Gland;
Thyroid Neoplasms
- From:Korean Journal of Pathology
2011;45(4):428-433
- CountryRepublic of Korea
- Language:English
-
Abstract:
A hyalinizing trabecular adenoma (HTA) is a rare benign thyroid tumor of follicular epithelial cell origin with a trabecular-alveolar growth pattern and marked intratrabecular hyalinization. The cytological and histological features of HTA are very similar to those of papillary and medullary carcinomas of the thyroid. Therefore, an accurate diagnosis of HTA is important to avoid unnecessary and potentially harmful management of patients. However, the results of BRAF gene mutation analysis shown by many studies are distinctly different between HTAs and papillary thyroid carcinomas. Herein, we describe a rare case of HTA of the thyroid in a 49-year-old female and consider its characteristic cytological features and BRAF gene mutation analysis results with a brief review of the literature.
