Liquid-Based Pap Smear Findings of Uterine Cervical Lymphoma: Three Cases Report.
- Author:
Jiyoung KIM
1
;
Hyesun KIM
;
Sung Ran HONG
;
Yi Kyeong CHUN
;
Hy Sook KIM
Author Information
1. Department of Pathology, Cheil General Hospital, KwanDong University College of Medicine, Seoul, Korea. hysook.kim@cgh.co.kr
- Publication Type:Case Report
- Keywords:
Cervix;
Lymphoma;
Liquid-based cytology;
Surepath
- MeSH:
Cervix Uteri;
Chromatin;
Female;
Humans;
Lymphocytes;
Lymphoma;
Lymphoma, B-Cell
- From:Korean Journal of Pathology
2011;45(4):437-440
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Malignant lymphoma of the uterine cervix is rarely diagnosed by cytology because it presents as a subepithelial mass. We report three cases of diffuse large B-cell lymphoma in the uterine cervix with a description of liquid-based pap smear (LBP) findings. All patients were presented with cervical masses, but a suspicion of malignant lymphoma was made in only one case by preoperative LBP. The LBP of two cases showed several atypical lymphoid cells in a clear background. The other case revealed numerous atypical lymphoid cells in a necrotic background. Most tumor cells had an increased N/C ratio, round but focally irregular nuclei, coarse chromatin, and prominent nucleoli. Nuclear blebing, dimpling, and multi-lobulation were also found. Diagnosis of malignant lymphoma by LBP is usually more difficult than by conventional techniques, because of a sparse numbers of cells and the lack of necrotic background. However, well preserved morphological features and a better resolution of nuclear details could be the benefits of LBP.
