Clinical Study on Adult Onset Still's Disease.
- Author:
Yun Seok YANG
1
;
Min Kyung SHIN
;
Seung Jae HONG
;
Yeon Ah LEE
;
Mu Hyoung LEE
Author Information
1. Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea. mhlee@khmc.or.kr
- Publication Type:Original Article
- Keywords:
Adult onset Still's disease;
Clinical features;
Cutaneous lesions
- MeSH:
Adult;
Age of Onset;
Arthralgia;
Arthritis;
Exanthema;
Female;
Fever;
Humans;
Inflammation;
Lymphatic Diseases;
Medical Records;
Pharyngitis;
Pigmentation;
Purpura;
Skin;
Still's Disease, Adult-Onset;
Thigh;
Urticaria;
Vasculitis;
Vasculitis, Leukocytoclastic, Cutaneous
- From:Korean Journal of Dermatology
2010;48(5):388-394
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disease of an unknown etiology, and this is characterized by spiking fever, evanescent rash, arthritis and multiorgan involvement. OBJECTIVE: This study was conducted to better understand the clinical characteristics of patients with AOSD, and especially the cutaneous features. METHODS: We reviewed the medical records and cutaneous findings of 21 patients who were diagnosed with AOSD at our hospital from 2003 to 2009. The diagnosis of AOSD was based on the criteria proposed by Yamaguchi et al. RESULTS: Eighteen (86%) out of the 21 patients were women, and the age of onset ranged from 18 to 55 years. Fever occurred in 21 (100%) patients, skin rash in 20 (95%), arthralgia in 18 (86%), sore throat in 10 (48%) and lymphadenopathy in 7 (33%). The cutaneous features were as follows: typical maculopapular eruption (70%), urticaria (10%), petechia and purpura (10%), persistent plaques and linear pigmentation (5%) and acne-like lesions (5%). The most common sites of skin lesion were the trunk (80%) and thighs (80%). The histopathologic findings of 9 patients showed non-specific chronic inflammation with a perivascular mononuclear preponderance in 6 patients, and the others were consistent with urticaria or leukocytoclastic vasculitis. CONCLUSION: The various cutaneous features of this study suggest that dermatologists should consider AOSD in any patient with cutaneous eruption associated with fever and arthralgia.
