A Case of Squamous Cell Carcinoma of the Liver in a Patient with Arsenic Keratosis Associated with Multiple Bowen's Disease.
- Author:
Eun Ah LEE
1
;
Hei Sung KIM
;
Hyung Ok KIM
;
Young Min PARK
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. yymmpark6301@hotmail.com
- Publication Type:Case Report
- Keywords:
Arsenic keratosis;
Bowen's disease;
Squamous cell carcinoma of liver
- MeSH:
Arsenic;
Asian Continental Ancestry Group;
Bowen's Disease;
Carcinoma, Squamous Cell;
Follow-Up Studies;
Herbal Medicine;
Humans;
Keratosis;
Liver;
Middle Aged;
Neoplasm Metastasis;
Skin Neoplasms
- From:Korean Journal of Dermatology
2010;48(5):424-428
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Arsenic keratosis can be a precursor of both Bowen's disease and squamous cell carcinoma. In fact, there is a direct dose-response relationship between the amount of arsenic exposure and the development of skin cancer. Therefore, meticulous dermatologic surveillance and follow-up are advised to detect malignancy at an early and curable stage. We herein report on a case of a 62-year-old man who presented with multiple Bowen's disease and arsenic keratosis. His past history revealed chronic exposure to arsenic through consumption of Chinese traditional herbal medicine. After a follow-up loss of 2 years, he returned with multiple extracutaneous metastases of squamous cell carcinoma, including the liver. Our case emphasizes the importance of regular follow-up and survey for skin cancer and other internal malignancies in patients with history of chronic arsenic exposure.
