Cytomegalovirus Diseases in AIDS Patients.
- Author:
Hong Bin KIM
1
;
Sang Won PARK
;
Nam Joong KIM
;
Hee Jung CHOI
;
Dong Hyeon SHIN
;
Myoung Don OH
;
Woo Ho KIM
;
Hum Chung CHUNG
;
Kang Won CHOE
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cytomegalovirus;
Human immunodeficiency virus;
AIDS;
Retinitis;
Opportunistic infection
- MeSH:
Colitis;
Cytomegalovirus*;
Diagnosis;
Esophagitis;
Follow-Up Studies;
Ganciclovir;
HIV;
HIV Infections;
Humans;
Immunoglobulin G;
Korea;
Lymphocyte Count;
Medical Records;
Opportunistic Infections;
Pneumonia;
Retinitis;
Seoul;
Seroepidemiologic Studies
- From:Korean Journal of Infectious Diseases
1998;30(4):358-364
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cytomegalovirus (CMV) infection is one of the important opportunistic infections in immuno-compromised patients. In Korea, seroprevalence of IgG against CMV is over 95%. Therefore, CMV diseases are expected to be a prevalent opportunistic infection in AIDS patients in Korea. METHODS: We reviewed the medical records of 128 patients with HIV infection who visited the Seoul Na-tional University Hospital during the period from Nov. 1987 to Sep. 1996. All the patients were examined by one ophthalmologist and the diagnosis of CMV retinitis were made by funduscopic findings. Other CMV dise-ases were diagnosed when histopathologic examinations showed the characteristic cytomegalic cells. RESULTS: Median duration of follow-up was 8 (0 ~ 59) months. Eleven CMV diseases were found in 7 patients (5.4%) : 6 patients had retinitis, 2 esophagitis, 1 colitis, 1 pneumonitis, and one patient developed disse-minated infection. Fifteen percent (6/33) of the patients whose CD4 + lymphocyte counts were less than 200/ mm 3 at baseline developed CMV diseases. Out of the 9 cases treated with ganciclovir, 7 improved or were stabi-lized. No patient received maintenance treatment and 3 had relapsed. CONCLUSION: CMV diseases are common opportuni-stic infections in AIDS patients in Korea.
