Skin Biopsy: Emerging Method for Small Nerve Fiber Evaluation.
10.14253/kjcn.2015.17.2.53
- Author:
Eun Hee SOHN
1
Author Information
1. Department of Neurology, Chungnam National University Hospital, Daejeon, Korea. seh337@daum.net
- Publication Type:Review
- Keywords:
Skin biopsy;
Small fiber neuropathy;
Intraepidermal nerve fiber
- MeSH:
Antibodies;
Biopsy*;
Dermis;
Epidermis;
Erythromelalgia;
Humans;
Nerve Fibers*;
Skin*
- From:Korean Journal of Clinical Neurophysiology
2015;17(2):53-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Skin biopsy with investigation of small nerve fiber in human epidermis and dermis has been proven to be a useful method for demonstration of small fiber neuropathy. Quantification of intraepidermal nerve fiber density using anti-Protein Gene Product 9.5 (PGP 9.5) antibody is standardized method to diagnose the small fiber neuropathy. Skin biopsy method also makes it possible to differentiate the type of nerve fibers by using different antibodies. Quantification of dermal structures with different type of nerve fibers could be used to invest pathophysiologic mechanism of diseased state.
