p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach.
10.3346/jkms.2002.17.4.490
- Author:
Sung Soo KIM
1
;
Choon Sang BHANG
;
Ki Ouk MIN
;
Hiun Suk CHAE
;
Sang Wook CHOI
;
Chang Don LEE
;
Keun Woo LIM
;
In Sik CHUNG
;
Doo Ho PARK
Author Information
1. Division of Gastroenterology, Department of Internal Medicine,College of Medicine, Catholic University of Korea, Seoul, Korea. dhpart@catholic.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Intestines;
Metaplasia;
Subtype;
Genes p53;
Mutation;
Microsatellite Repeats
- MeSH:
Carcinoma/genetics/pathology;
Exons;
*Genes, p53;
Humans;
Metaplasia/genetics/pathology;
*Microsatellite Repeats;
*Mutation;
Precancerous Conditions;
Stomach/*pathology;
Stomach Neoplasms/genetics/pathology;
Tumor Suppressor Protein p53/genetics/metabolism
- From:Journal of Korean Medical Science
2002;17(4):490-496
- CountryRepublic of Korea
- Language:English
-
Abstract:
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI) both in the complete type (type I) and in the sulphomucin-secreting incomplete type (type III) intestinal metaplasia located adjacent to the gastric carcinoma. p53 mutations were observed in 13.3% of type I, in 6.6% of type III intestinal metaplasia, and in 40% of gastric carcinoma. The difference between p53 mutations observed in type I and type III intestinal metaplasia was not statistically significant. No identical mutation of the p53 gene was found in the intestinal metaplasia and carcinoma specimens from the patients. There was no case of intestinal metaplasia showing MSI. In gastric carcinomas, MSI was observed in six cases (40%). The cases harboring BAT-26 instability did not have the mutation of the p53 gene. These data suggest that intestinal metaplasia adjacent to gastric carcinoma, irrespective of its subtype, do not have the genetic alterations as showing in their carcinoma tissues.
