Synergetic Hepatoprotective Effects of Korean Red Ginseng and Pueraria Radix on the Liver Damaged-Induced by Carbon Tetrachloride (CCl₄) in Mice.
10.20307/nps.2017.23.2.132
- Author:
Seung Hwan HWANG
1
;
Zhiqiang WANG
;
Il Jun KANG
;
Soon Sung LIM
Author Information
1. Department of Food Science and Nutrition, Hallym University, 1 Hallymdeahak-gil, Chuncheon 24252, Republic of Korea. limss@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
Carbon tetrachloride;
Red Ginseng;
Pueraria Radix;
Hepatoprotective;
Synergetic
- MeSH:
Acetic Acid;
Animals;
Carbon Tetrachloride*;
Carbon*;
Cats;
Liver*;
Mice*;
Mice, Inbred ICR;
Panax*;
Pueraria*;
Water
- From:Natural Product Sciences
2017;23(2):132-138
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was designed to investigate the synergetic hepatoprotective effects from a mixture of Korean Red Ginseng and Pueraria Radix on carbon tetrachloride (CCl₄)-induced hepatotoxicity in mice. Liver toxicity was induced by intraperitoneal administration of CCl₄ (0.6 mg/kg) in 12 groups of ICR mice. The negative control group was given CCl₄ without test samples and the normal group was given no treatment. Among treatment groups, the RGAP treatment (Korean Red ginseng acetic acid extract : Pueraria Radix water extract, w/w, 38.4:57.6) decreased CCl₄-elevated ALT (101.60 IU/L), AST (833.89 IU/L), and LDH (365.02 IU/L) levels in the serum, and increased the SOD (11.03 unit/mg protein) and CAT (0.37 unit/mg protein) levels and the LPO levels (59.09 µM/g tissue) more than that in the mice group with CCl₄-induced control group hepatotoxicity. These results suggest that administration of a mixture of Korean Red ginseng and Pueraria Radix decreases CCl₄-induced liver damage and enhances antioxidant activity in mice and imply that administration of the mixture in a certain ratio is more effective than single administration of either Korean Red ginseng or Pueraria Radix alone.
