A Case of Early Stage Mycosis Fungoides that was Successfully Treatedwith a Combination Therapy of PUVA and Interfernon-gamma.
- Author:
Kwang Ho YOO
1
;
Yeon Jin KIM
;
Yong Kwan RHO
;
Ju Hee PARK
;
Ji Young KIM
;
Kapsok LI
;
Seong Jun SEO
;
Chang Kwun HONG
Author Information
1. Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Korea. drseo@hanafos.com
- Publication Type:Case Report
- Keywords:
Early stage mycosis fungoides;
Interfernon-gamma;
PUVA
- MeSH:
Administration, Intravenous;
Adrenal Cortex Hormones;
Electrons;
Ficusin;
Humans;
Interferon-gamma;
Mycosis Fungoides;
Photochemotherapy;
Psoralens;
Recurrence;
Ultraviolet Rays
- From:Korean Journal of Dermatology
2008;46(10):1402-1406
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Early stage mycosis fungoides (MF) is known to be responsive to various topical and systemic therapies such as corticosteroids and ultraviolet light radiation, photochemotherapy with psoralens and whole-body electron beam irradiation. However, these treatments have all revealed a high relapse rate. Thus, we suggest that more invasive therapy, including PUVA combined with interferon-gamma, is one of the possible treatments for early MF because this treatment displays a reduced relapse rate. We report here on a case of early stage MF (Stage Ib) that was successfully treated with PUVA (total dose: 105.7 J/cm2) and intravenous administration of recombinant human interferon-gamma (total 5.4x10(6) IU), and the patient has been without relapse 1 year after treatment.
