A Case of CD30 (+)/ALK (-) Primary Systemic AnaplasticLarge Cell Lymphoma with Atypical Clinical Features.
- Author:
Yun Seok YANG
1
;
Ki Heon JEONG
;
Hee Ryung CHO
;
Choong Rim HAW
;
Nack In KIM
Author Information
1. Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea. nikim@khmc.or.kr
- Publication Type:Case Report
- Keywords:
ALK;
Anaplastic large cell lymphoma;
CD30;
Primary systemic ALCL
- MeSH:
Buttocks;
Korea;
Lower Extremity;
Lymphocytes;
Lymphoma;
Lymphoma, Large-Cell, Anaplastic;
Lymphoma, Non-Hodgkin;
Lymphomatoid Papulosis;
Lymphoproliferative Disorders;
Phosphotransferases;
Receptor Protein-Tyrosine Kinases;
Skin
- From:Korean Journal of Dermatology
2008;46(10):1419-1423
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin's lymphoma, and this tumor is predominantly composed of large lymphoid cells that have a strong expression of CD30. Two major groups of ALCL have been described. The first is a spectrum of CD30+ lymphoproliferative disorders, including primary cutaneous ALCL and lymphomatoid papulosis. The second is systemic nodal ALCL, which can be subdivided into two groups: anaplastic lymphoma kinase (ALK)-positive and ALK-negative. The relative frequency of ALCL in Korea is about 19% of all cutaneous lymphomas. Solitary or multiple large nodular tumoral lesions confined to one body compartment are the most common presentation. We report here on a case of CD30 (+)/ALK (-) primary systemic ALCL in a 77 year-old-male, and the skin lesion manifested as multiple papules, plaques and tumors on the trunk, buttocks and upper and lower extremities.
