Effect of Platelet-rich Plasma(PRP) on Regeneration of Rat Sciatic Nerve in a Silicone Chamber.
- Author:
Kyung Won MINN
1
;
Eui Cheol JEONG
;
Hak CHANG
;
Sung Tack KWON
;
Suk Wha KIM
;
Rong Min BAEK
Author Information
1. Department of Plastic and Reconstructive Surgery, Research Institute of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Nerve regeneration;
Platelet-rich plasma;
Sciatic nerve;
Entubulation
- MeSH:
Animals;
Biopsy;
Light;
Muscles;
Nerve Regeneration;
Peripheral Nerve Injuries;
Platelet-Rich Plasma;
Rats;
Rats, Inbred Lew;
Regeneration;
Sciatic Nerve;
Silicones
- From:Journal of the Korean Society of Plastic and Reconstructive Surgeons
2010;37(2):105-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study is to determine the effect of platelet-rich plasma(PRP) on rat sciatic nerve regeneration in a 10mm silicone chamber. METHODS: A total of 6 inbred Lewis rats were used in this study. Bilateral sciatic neurectomy was performed on each rat. On one side, silicone chambers containing PRP solutions were implanted; on the contralateral side, the chambers without PRP were implanted as a control. In 12 weeks post-implantation, chambers were retrieved and both gastrocnemius muscles were excised. Nerves biopsy samples were examined under a light microscope after Masson trichrome staining. RESULTS: Cross sections of the midpoints of PRP treated nerves were significantly larger and appeared more mature than those of controls. CONCLUSION: Based on morphological evidence, PRP has a positive effect on neural regeneration, and it may therefore be useful for treating peripheral nerve injuries.
