Clinical Significance of Serum Concentration of Intercelluar Adhesion Molecule-1 in Patients with Acute and Chronic Liver Disease.
- Author:
Sung Shick LIM
1
;
Seok Ho DONG
;
Hyo Jong KIM
;
Byung Ho KIM
;
Joung Il LEE
;
Rin CHANG
Author Information
1. Department of Internal Medicine, Kyung Hee University School Of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
ICAM-1;
acute and chronic liver disease
- MeSH:
Alcoholics;
Classification;
Drug-Induced Liver Injury;
Enzyme-Linked Immunosorbent Assay;
Hepatitis;
Hepatitis B;
Hepatitis, Chronic;
Humans;
Inflammation;
Intercellular Adhesion Molecule-1;
Liver Cirrhosis;
Liver Cirrhosis, Alcoholic;
Liver Diseases*;
Liver*
- From:The Korean Journal of Hepatology
1996;2(1):68-76
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Recent studies, have examined the expression of adhesion molecules in liver inflammation, and the existence of soluble ICAM 1 in serum could be proved by ELISA. We maeasured s-ICAM 1 in patients with acute and ehronic liver disease to see the level of s-ICAM 1 can reflect degree of necroinflammation or progress of disease. METHOD: Serum levels of soluble forms of intercellular adhesion molecule 1(sIGAM 1) in 78 patients with acute and chronic liver disease including acute hepatitis B, CAH, C.'PH, post-necrotic and alcoholic liver cirrhosis, hepatoceliular carcinoma, toxic hepatitis were measured by enzyme-linked immunosorbent assays. RESULTS: 1) ICAM 1 semm levels in acute and chronic liver disease including acute hepatitis B(709.6+/-321.7 ng/L, p<0.001), C:AH(582.2+/-312.4 ng/L, p<0.001), CPH(357,8+/-135.0 ngL, p<0.044), postnecrotic livercirrhosis(716.2+/-348.0 ng/L, p<0.0001), alcoholic liver cirrhosis(763.3+/-48l.5 ng/L, p<0.009). Hepatocellular carcinoma(728.2+/-329.0 ng/L, p<0.002), toxic hepatitis(817.3+/-324.4 ng/l, p<0.0001) were signiticantly higher than that of healthy controLs(234.5+/-67.5 ng/L).2) In comparison with CPH we found significantly increased ICAM- 1 serum levels in CAH.(p=0.027) A significant correlation was found between the ICAM-1 serum level and the histologically graded inflammatory activity in CAH. 3) No correlation was found be1ween the ICAM l serum level aml the Child- Pugh classification in liver cirrhosis. 4) In comparison with chronic hepatitis we found signitcantly increased 1CAM 1 serum levels in liver cirrhosis(p = 0.001) , and in hepatocellular carcinoma(p = 0.0001). CONCLUSION: Soluble ICAM I serum level correlated well with ongoing necrointlammatory activity in acute and chronic hepatitis and also slCAM 1 can reflect disease severity in various chronic 1iver disease groups.
