A Case of Hypothyroidism Induced by Alpha-Interferon Therapy for Chronic Hepatitis B.
- Author:
So Young KWON
;
Jong Eun YEON
;
Sei Hyun BAIK
;
Jin Ho KIM
;
Young Tae BAIK
;
Kwan Soo BYUN
;
Chang Hong LEE
- Publication Type:Case Report
- Keywords:
Chronic hepatitis B;
Alpha-interferon;
Hypothyroidism
- MeSH:
Hepatitis B, Chronic*;
Hepatitis, Chronic*;
Humans;
Hypothyroidism*;
Incidence;
Interferon-alpha*;
Middle Aged;
Thyroid Gland
- From:The Korean Journal of Hepatology
1996;2(1):77-81
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thyroid dysfunction has heen reported as a side effect of alpha-interferon(IFN) therapy. The incidence of thyroid disorders was 1.2-12%' duripg 1FN therapy for chronic active hepatitis. We experienced a case of hypothyroidism developed after IFN therapy in a 48 year-old man with chronic hepatitis B. Baseline thyroid function before IFN therapy was normal and thyroid auioantibodies were also negative. High tiers ol' antimicrosomal antibody and anti-thyroglobulin antibody appeared and severe hypothyroidism followed at 6 months after starting the IFN therapy.
