A Case of IgG4-Related Disease with Bronchial Asthma and Chronic Rhinosinusitis in Korea.
10.3346/jkms.2014.29.4.599
- Author:
Young Soo LEE
1
;
Hyo Jeong CHO
;
Hye Soo YOO
;
Yoo Sub SHIN
;
Hae Sim PARK
Author Information
1. Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr
- Publication Type:Case Reports
- Keywords:
IgG4-Related Disease;
Asthma;
Bronchitis, Chronic
- MeSH:
Asthma/complications/*diagnosis;
Chronic Disease;
Creatinine/blood;
Female;
Humans;
Immunoglobulin G/*blood;
Middle Aged;
Pancreas/enzymology;
Plasma Cells/physiology;
Prednisolone/therapeutic use;
Republic of Korea;
Rhinitis/complications/*diagnosis/drug therapy;
Sinusitis/complications/*diagnosis/drug therapy;
Submandibular Gland/pathology;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2014;29(4):599-603
- CountryRepublic of Korea
- Language:English
-
Abstract:
IgG4-related disease (IgG4-RD) is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasmacytes. We experienced a case of IgG4-RD developed in a patient with bronchial asthma (BA) and chronic rhinosinusitis (CRS). A 55-yr-old female patient with BA and CRS complained of both eyes and neck swelling as well as a recurrent upper respiratory infection in recent 1 yr. The serum levels of IgG4, creatinine, and pancreatic enzymes were elevated. A biopsy of the submandibular gland showed an abundant infiltration of IgG4-positive plasmacytes. Her symptoms remarkably improved after the treatment of a systemic steroid that has been maintained without recurrence. We report a rare case of IgG4-RD developed in a patient with BA and CRS.
