Normative Data on Serum Levels of IGF-I, IGFBP-3 in Healthy Korean Children: Effect of Age, Sex, Height, Body Mass Index, and Pubertal Maturation on the Serum Levels.
- Author:
Jin Kyong CHUN
1
;
Jae Bok KIM
;
Han Wook YOO
Author Information
1. Department of Pediatrics, COllege of Medicine, University of Ulsan, Seoul, Korea. hwyoo@www.amc.seoul.kr
- Publication Type:Original Article
- Keywords:
IGF-I;
IGFBP-3;
Normative data
- MeSH:
Adolescent;
Body Height*;
Child*;
Growth Hormone;
Humans;
Insulin-Like Growth Factor Binding Protein 3*;
Insulin-Like Growth Factor I*;
Korea;
Puberty
- From:Journal of Korean Society of Pediatric Endocrinology
2000;5(1):75-82
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was undertaken to obtain the normative data on serum levels of IGF-I and IGFBP-3 in healthy Korean children and to evaluate the effects of age, sex, height, body mass index and pubertal maturation on the serum levels of IGF-I and IGFBP-3. METHODS: This study included 301 healthy Korean subjects in pediatric age group. Serum levels of IGF-I and IGFBP-3 were measured twice using IRMA kit in each individual. The correlations between the serum levels of IGF-I or IGFBP-3 and age, auxological data or children's Tanner stages were evaluated. RESULTS: Serum levels of IGF-I and IGFBP-3 increased in proportion to age progression, and their rates of increase were remarkable shortly before and during the puberty. The correlations between serum levels of IGF-1 and age, sex, height standard deviation scores, BMI, or pubertal maturation were significant(P<0.05). However, the serum levels of IGFBP-3 was correlated only with height standard deviation scores(P<0.05). There was a significant positive correlation between serum levels of IGF-1 and those of IGFBP-3(P<0.001). CONCLUSION: Although IGF-I and IGFBP-3 assays can be utilized for the evaluation of endogenous growth hormone status, the effects of age, sex, BMI, height and pubertal development on the levels of IGF-I and IGFBP-3 must be considered. Therefore, these results would be helpful as a normative data for the growth evaluation of children in Korea.
