Estrogen Receptor Gene Polymorphism (PvuII and XbaI) and Outcomes of Controlled Ovarian Hyperstimulation for In-vitro Fertilization and Embryo Transfer.
- Author:
Kyu Ri HWANG
1
;
Young Min CHOI
;
Ji Sung YOON
;
Won Don LEE
;
Seung Yup KU
;
Byung Chul JEE
;
Chang Suk SUH
;
Seok Hyun KIM
;
Jung Gu KIM
;
Shin Yong MOON
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Estrogen receptor;
Polymorphism;
In-vitro fertilization and embryo transfer (IVF-ET);
Controlled ovarian hyperstimulation
- MeSH:
Embryo Transfer*;
Embryonic Structures*;
Estradiol;
Estrogen Receptor alpha;
Estrogens*;
Female;
Fertilization*;
Genotype;
Gonadotropins;
Humans;
Oocytes;
Pregnancy Rate
- From:Korean Journal of Obstetrics and Gynecology
2004;47(8):1552-1557
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of this study was to investigate the association of the estrogen receptor alpha gene polymorphism (PvuII and XbaI) with outcomes of controlled ovarian hyperstimulation for in- vitro fertilization and embryo transfer (IVF-ET). METHODS: The PvuII and XbaI in the estrogen receptor gene was analyzed by PCR-RFLP in 189 infertile women undergoing controlled ovarian hyperstimulation for in-vitro fertilization and embryo transfer. Comparisons were done between the three PvuII or XbaI genotypes, concerning the numbers of follicles and oocytes, the ratio of oocytes to follicles, serum estradiol concentrations, total dose of gonadotropins, number of transferred embryos, implantation rate and pregnancy rate. RESULTS: In this study, there was no statistically significant difference in outcomes of controlled ovarian hyperstimulation, except total dose of gonadotropins used among three genotypes of PvuII or XbaI polymorphism. CONCLUSION: These results suggest that the PvuII and XbaI polymorphisms of the estrogen receptor gene are not associated with the outcomes of controlled ovarian hyperstimulation for IVF-ET in Korean infertile women.
