Growth Hormone Treatment for Fanconi Anemia with Growth Hormone Deficiency.
- Author:
Min Kyoung KIM
1
;
Min Jae KANG
;
Hye Rim CHUNG
;
Choong Ho SHIN
;
Sei Won YANG
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. chshinpd@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Fanconi anemia;
Growth hormone deficiency
- MeSH:
Fanconi Anemia;
Follow-Up Studies;
Growth Hormone;
Humans;
Hypopituitarism;
Hypothyroidism;
Stem Cell Transplantation
- From:Journal of Korean Society of Pediatric Endocrinology
2010;15(3):198-202
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Short stature is common in case of Fanconi anemia (FA) and may result from inherent abnormalities of FA or endocrinopathies, such as a growth hormone deficiency and hypothyroidism. Growth hormone treatment in FA patients with growth hormone deficiency (GHD) has been controversial because FA itself has a risk of malignancy, and there has been a concern about the increased risk of malignancy from growth hormone treatment. We report on an FA boy with GHD who was diagnosed with FA and undertook stem cell transplantation. Because he showed severe growth failure, growth hormone therapy was initiated at 6 years of age, after he was diagnosed with hypopituitarism, including GHD. He expressed significant catch-up growth with no complications beyond the two year follow up period. This case suggests that growth hormone therapy can be considered in patients with GHD caused by FA, with careful monitoring for malignancy.
