The Therapeutic Effect of Drug in Parkinson's Disease.
- Author:
Il Saing CHOI
1
;
Myung Sik LEE
;
Young Jin LEE
;
Won Young CHUNG
;
Sung Soo LEE
;
Won Tsen KIM
Author Information
1. Department of Neurology, Yong Dong Severance Hospital, College of Medicine, Yonsei University.
- Publication Type:Original Article
- MeSH:
Carbidopa;
Central Nervous System;
Drug Therapy;
Dyskinesias;
Dystonia;
Humans;
Levodopa;
Myoclonus;
Parkinson Disease*;
Parkinsonian Disorders;
Pneumonia;
Prognosis;
Psychomotor Agitation;
Psychotic Disorders
- From:Journal of the Korean Neurological Association
1989;7(1):19-25
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Two hundred and four patients with Parkinson's disease initially treated wth a combination of levodopa and carbidopa ( Sinement 25-250 ) and / or anticholinergic drugs. All patients responded initially to drug. Sixteen patients(7.8%) had 20 acute central nervous system side effects: 8, dyskinesia: 6, visual hallucination:5, psychosis: and 1, akathisia. The response to treatment usually was stable for the first one and a half to four years of drug therapy. Subsequently, over 50 percent of patients had therapeutic failure among 82 patients with long term drug therapy, fourteen(l7.0%) had 18 side effects: 8, on-off phenomenon: 4. Morning dystonia: 3, dyskinesia:and 3, simultaneous dyskinesia with parkinsonism. None had diphasic dyskinesia or myoclonus. The prognosis of the demented parkinsonian was relatively poor. Two patients died due to pneumonia and ovarian carcinoma.
