Effect of Capsaicin on Immune Responses, Anaphylaxis and Tumorigenesis in Mice.
- Author:
Tai You HA
;
Won Jae SONG
;
Jae Seung PARK
;
Yoo Seung KO
;
Hyun Ju HA
- Publication Type:Original Article
- Keywords:
Capsaicin;
Anaphylaxis;
Immune responses;
Tumorigenesis;
TNF-a;
Mitogen responses;
Neurotoxin
- MeSH:
Anaphylaxis*;
Animals;
Capsaicin*;
Carcinogenesis*;
Cytokines;
Immune System;
Immunity, Humoral;
Immunization;
Mice*;
Neck;
Neuropeptides;
Sensory Receptor Cells;
Tachykinins
- From:Korean Journal of Immunology
1997;19(2):229-244
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It has been known that the interconnection between the gervous, endocrine and immune system are largely mediated through regulatory soluble factors such as neruopeptides, cytokines and hormones. Capsaicin, the pungent principle of hot peppers, is a neurotoxin that affects primary sensory neurons of the C and A-b type and depletes primary sensory neurons (polymodal nociceptors) of neuropeptides like tachykinin. In this study capsaicin was used to explore the possible role of the neruons on the expression of cellular and humoral immune responses and TNF-a prodcution. Mice were pretreated with s.c. injections in the neck region with a single dose of 100 u,g of capsaicin per mouse before immunization. ...continue...
