Apoptosis of Fas Expressed Target Cells Induced by Cytotoxic T Lymphocytes.
- Author:
Sang Ho KIM
;
Su Young KIM
- Publication Type:Original Article
- Keywords:
CTL;
Fas;
FasL;
Genistein;
ICE;
Apoptosis
- MeSH:
Apoptosis*;
Cell Death;
Epithelial Cells;
Genistein;
Ice;
Killer Cells, Natural;
Ligation;
Metabolic Networks and Pathways;
Receptors, Tumor Necrosis Factor;
Signal Transduction;
T-Lymphocytes, Cytotoxic*
- From:Korean Journal of Immunology
1997;19(2):245-262
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cytotoxic T lymphocytes (CTL) playing an important role in e cell-mediated immune response kill the target cells by the special contact-dependent mechanism. It has been known that CTL and NK cells utilize two different pathways in removing specific target cells: apoptotic cell death and osmotic lysis by the pore forming protein. Interaction of CTL with target cells results in the ligand-induced, receptor-mediated, nonsecretory lytic process and lethal hit is delivered by the transducing molecule, Fas (CD95, APO-1), one of the TNFR/NGFR superfamily. In addition, ligation of TNF receptor and CD40 also induced the apoptosis of B cell and epithelial cells. However, recognition of target cells, the triggering mechanism, cytotoxic mediators, internal metabolic pathway and signal transduction behind apoptosis remain undefined and have been elucidated only in part. ...continue...
