Study on the Immunologic Mechanism in the Xenogenic Transplantation.
- Author:
Duck Jong HAN
;
Hee Man LEE
;
Song Cheol KIM
;
You Me WE
;
Heui Yeon KANG
;
Jeong Yeun KIM
;
Eun Sil YU
;
Song Hoe PARK
- Publication Type:Original Article
- Keywords:
Xenograft;
Antibody;
Complement
- MeSH:
Antibodies;
Complement System Proteins;
Heterografts;
Humans;
Organ Transplantation;
Tissue and Organ Procurement;
Tissue Donors;
Transplantation, Heterologous;
Transplants
- From:Korean Journal of Immunology
1997;19(2):277-288
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Organ transplantation has become a' widely accepted treatment modality for end-stage organ disease. The shortage of allogenic donors for organ transplantation has brought about the necessity of xenotransplantation as an unlimited source of organ donation. However, organ transplantation between different species have never been successful because of hyperacute rejection. Although the mechanism of this phenomenon is not fully understood, many researchers believe that the natural antibodies present in the recipient's serum may bind to the graft and induce the activation of complement cascade triggering the process of hyperacute rejection. ...continue...
