Serum Phospholipase A2 Activities in Patients with Chronic Liver Disease.
- Author:
Jong Myung LEE
;
Young Oh KWEON
;
Nung Soo KIM
- Publication Type:In Vitro ; Original Article
- Keywords:
Phospholipase A2;
Chronic liver disease;
Endotoxin;
Cytokines170
- MeSH:
Arachidonic Acid;
Cytokines;
Fibrosis;
Hepatitis;
Hepatitis B, Chronic;
Humans;
Liver Cirrhosis;
Liver Diseases*;
Liver*;
Membranes;
Phospholipases A2*;
Phospholipases*;
Phospholipids;
Radioactivity;
Serum Albumin
- From:The Korean Journal of Hepatology
1997;3(2):170-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/PURPOSE: Phospholipase A (PLAq) is an rate-limiting enzyme hydrolyzing arachidonic acid from the sn-2 position of membrane phospholipids. In vitro studies demonstrated that the enzyme could be secreted into extracellular mileu by pro-inflammatory cytokines and endotoxin which were reported to have important roles in chronic liver diseases. This study was performed to know whether the enzyme is involved in the pathophysiology of the diseases. METHODS: The subjects were composed of 24 patients with chronic hepatitis B, 26 patients with liver cirrhosis and 14 healthy individuals. The PLAp activities wem measured in the sera of the subjects by detecting radioactivity of "C-fatty acid hydrolyzed from "C-labeled phosphotadylethanolamine by the enzyme. RESULTS: The activities of PLA were increased in the patients with chronic liver diseases, especially in the chronic hepatitis B patients with acute exacerbation and in the decompensated cirrhosis patients. Furthermore, their activities were closely related with the levels of transaminase in hepatitis group and with the levels of serum albumin in cirrhosis group, respectively. CONCLUSIONS: These results suggest that extracellular PLA might be involved in the exacerbution and progression of the chronic liver diseases.
