Comparison Between a New Low Dose Urea Capsule Test and the Conventional UBiT(R) Tablet Test for the Detection of Helicobacter pylori Infection.
10.3343/kjlm.2006.26.2.81
- Author:
Seo Jin PARK
1
;
Youn Hee PARK
;
Sang In LEE
;
Duk Chul LEE
;
Dongeun YONG
;
Jeong Ho KIM
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. jeongho@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Urea breath test;
Helicobacter pylori;
Low-dose urea
- MeSH:
Bias (Epidemiology);
Breath Tests;
Diagnosis;
Helicobacter pylori*;
Helicobacter*;
Informed Consent;
Urea*;
Urease;
Volunteers
- From:The Korean Journal of Laboratory Medicine
2006;26(2):81-85
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The urea breath test (UBT) is regarded as a highly reliable, noninvasive tool for diagnosing Helicobacter pylori infection. We compared a recently developed low-dose 38 mg 13C-urea capsule, which is able to eliminate oral urease effects and does not require positional changes during the test, with the conventionally used 100 mg 13C-urea tablet method. METHODS: Thirty-nine volunteers were tested under informed consent with both 13C-UBT methods, Helifinder(R) and UBiT-IR300(R), with a minimum 2-week washout period. The pre-ingestion and 20-minute post-ingestion breath samples were analyzed with an isotope ratio mass spectrometer for Helifinder, and a nondispersive isotope-selective infrared spectrophotometer for UBiT samples. RESULTS: Helifinder method showed excellent agreement with UBiT among 19 positive and 20 negative cases (weighted kappa value, 1.0). Helifinder results (y) showed good agreement but with a proportional bias compared to UBiT results (x) by Passing and Bablok method (y=0.551 X -0.255, r=0.74, P<0.0001). CONCLUSIONS: Since the low-dose 38 mg 13C-urea capsule (Helifinder) test, which is more convenient and economic, showed comparable results with the conventional UBiT method, it can be used as an alternative for the diagnosis of H. pylori infection.
