Comparison of Clinical Characteristics of Patients with Rotavirus Gastroenteritis Relative to the Infecting Rotavirus G-P Genotype.
10.3343/kjlm.2006.26.2.86
- Author:
Sook Jin JANG
1
;
Jung Oak KANG
;
Dae Soo MOON
;
Sung Hyun LEE
;
Ahn Gyun YEOL
;
Ok Yeon JEONG
;
Hu Lin HAN
;
Bidur Prasad CHAULAGAIN
;
Seong Sig CHO
;
Young Jin PARK
Author Information
1. Department of Laboratory Medicine, Chosun University Medical School, Gwangju, Korea. dsmoon@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Rotavirus;
G4P[6] strain;
Genotype;
Clinical features;
Nosocomial infection
- MeSH:
Child;
Cross Infection;
Dehydration;
Diarrhea;
Fever;
Gastroenteritis*;
Genotype*;
Humans;
Infant, Newborn;
Medical Records;
Polymerase Chain Reaction;
Rotavirus Infections;
Rotavirus*;
Vomiting
- From:The Korean Journal of Laboratory Medicine
2006;26(2):86-92
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Group A rotavirus is a major cause of severe diarrhea in children throughout the world. For the proper management of rotavirus infections, it will be helpful to know their clinical characteristics according to the G and P genotypes of the infecting virus. METHODS: The diarrheal stool specimens from patients hospitalized in Chosun University Hospital during 2002-2003 were tested for rotavirus by Dipstick 'Eiken' Rota kit. Rotavirus antigen-positive stool specimens were analyzed for group A rotavirus by RT-PCR, and the group A-positive PCR products were genotyped for P and G types by PCR. RESULTS: Among the 119 specimens analyzed for genotypes, the predominant strain was genotype G4P[6] (51.3%), followed by G2P[4] (19.3%), G1P[8] (7.6%), G3P[8] (5.0%), and G9P[8] (4.2%). To examine the characteristics of each rotavirus genotype, a clinico-epidemiological study was performed for 100 patients whose medical records were available. The frequencies of diarrhea, vomiting, dehydration, and fever; the rates of nosocomial infection and transfer from other hospitals; and the mean severity scores were significantly different among the patients infected with different types of rotavirus. Especially, patients with G4P[6] type were more likely than those infected with other genotypes to show the following distinct features: Most patients showed milder symptoms and were neonates transferred from other obstetric hospitals and 68.4% of the cases were nosocomial infection. G4P[6] strains were isolated almost all along the year. The mean severity scores of patients infected by G4P[6], G2P[4], G1P[8], G3P[8], and G9P[8] strains were 6.8, 9.5, 8.0, 9.0, and 10.8, respectively. CONCLUSIONS: Many features of rotavirus infections including the epidemic period, rate of nosocomial infection, age and severity of symptoms were different according to the genotypes of the infecting virus.
