Dosimetry and MIRD for Re-188 Liquid Balloons.
- Author:
Dong Soo LEE
;
Jin LEE
- Publication Type:Original Article
- Keywords:
Re-188 DTPA;
Dosimetry;
MIRD;
Restenosis
- MeSH:
Angioplasty;
Brachytherapy;
Pentetic Acid;
Rupture;
Urinary Bladder
- From:Korean Journal of Nuclear Medicine
1999;33(2):222-227
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Re-188 is suitable for endovascular liquid-balloon brachytherapy for the prevention of restenosis after angioplasty. Re-188 was concentrated to 3700 MBq/ml and labeled with DTPA. According to dosimetric calculation, it took 420 seconds using Re-188 solution with concentration of 3700 MBq/ml to irradiate 17.6 Gy to the target at 1 mm from the balloon surface. Software was made to estimate the irradiation time. MIRD calculation with dynamic bladder model yielded the whole body dose of Re-188-DTPA as 0.005mGy/MBq in case of balloon rupture and release of the whole amount into the blood.
