Gallium-67 Scintigraphy in Glomerular Disease.
- Author:
Woo Chul LEE
1
;
Sang Heun SONG
;
Hyun Chul JUNG
;
Soo Bong LEE
;
Ihm Soo KWAK
;
Ha Yeon RHA
Author Information
1. Department of Internal Medicine, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Gallium scintigraphy;
glomerulonephritis
- MeSH:
Biopsy;
Cholesterol;
Gallium;
Glomerulonephritis;
Glomerulonephritis, Membranoproliferative;
Glomerulosclerosis, Focal Segmental;
Hematuria;
Humans;
Hypertension;
Immunoglobulin A;
Liver;
Male;
Nephrotic Syndrome;
Proteinuria;
Radionuclide Imaging*;
Serum Albumin;
Spine
- From:Korean Journal of Medicine
1999;56(4):509-516
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Gallium 67(Ga-67) scintigraphy has been used to diagnose inflammatory and neoplastic diseases. We undertook a study to determine the clinical value of Ga- 67 renal scan in patients with various glomerular diseases. METHODS: Ga-67 scintigraphy was performed in 48 patients with various biopsy proven forms of renal diseases. Renal uptake in 48 patients images was graded as follow: Grade 0 = not visualization at 48 hours: 1 = faintly visualize: 2 = equal to uptake in spine: 3 = greater than over the spine: 4 = greater than activity over the liver. RESULTS: 1) Of the 48 patients, 31 were male, and mean age was 32 years. 11 patients had hypertension and 29 patients had hematuria. 2) Positive scintigram were seen in 40 of 48(83%) cases. In results of renal biopsy, IgA nephropathy(IgAN) was 15 patients, minimal change disease(MCD) was 14, focal segmental glomerulosclerosis (FSGS) was 8, membranoproliferative glomerulonephritis (MPGN) was 3, lupus nephritis(LN) was 3, poststreptococcal glomerulonephritis(PSGN) was 3 and membranous glomerulonephritis(MGN) was 2. 3) In 26 patients (54%) with nephrotic-range proteinuria, Grade 2 or higher renal uptake was observed in 9 (75%) of MCD, 5(100%) of FSGS, 2(100%) of LN and 3(75%) of IgAN. 4) In comparision nephrotics with non-nephrotics at biopsy, renal Ga-67 uptake in who patients had nephrotic-range proteinuria was correlated with clinical severity determined by serum albumin, serum total cholesterol and 24 hours urine protein excretion. CONCLUSIONS: Renal Ga-67 scintigraphy may be able to be a predictor in the assessment for severity of nephrotic syndrome.
