Expression of Cyclooxygenase (COX)-2 as a Prognostic Factor in Nasopharyngeal Cancer.
- Author:
Kyubo KIM
1
;
Hong Gyun WU
;
Suk Won PARK
;
Chong Jai KIM
;
Charn Il PARK
Author Information
1. Department of Therapeutic Radiology, Seoul National University College of Medicine, Korea. wuhg@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Cyclooxygenase-2;
Radiotherapy;
Nasopharyngeal cancer;
Prognostic factor
- MeSH:
Cyclooxygenase 2;
Drug Therapy;
Humans;
Nasopharyngeal Neoplasms*;
Neoplasm Metastasis;
Prostaglandin-Endoperoxide Synthases*;
Radiotherapy;
Recurrence;
Treatment Failure
- From:Cancer Research and Treatment
2004;36(3):187-191
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the relationship between treatment failure and COX-2 expression in nasopharyngeal cancer patients treated with chemotherapy and radiotherapy. MATERIALS AND METHODS: The subjects of this study were 22 nasopharyngeal cancer patients. The patients were treated with neoadjuvant chemotherapy, followed by radiotherapy, or with radiotherapy alone. The formalin- fixed, paraffin- embedded tissues of 11 patients who developed a locoregional recurrence (n=7) or distant metastasis (n=4) were compared with those of 11 disease free patients. Prognostic factors, including histological type, stage, radiation dose and chemotherapy, were well balanced between the two groups. The COX-2 expression was determined immunohistochemically. RESULTS: COX-2 expression was stronger in the patients with a locoregional recurrence or distant metastasis than in those free of disease. The COX-2 distribution scores of the control group were as follows: 0 in 7, 1 in 2 and 2 in 2 patients. In the recurrence group, the scores were as follows; 0 in 3, 1 in 1, 2 in 2 and 3 in 5 patients. COX-2 expression was shown to have a statistically significant influence on the treatment failure by the Mann-Whitney U test (p=0.024) and Mantel-Haenszel Chi-Square test (p=0.018). It also significantly influenced the treatment failure when an analysis was performed within patients with a undifferentiated histology (p=0.039 by the Mann- Whitney U test, p=0.037 by the Mantel-Haenszel Chi- Square test). CONCLUSION: COX-2 expression is believed to be one of the important factors associated with a locoregional recurrence or distant metastasis.
