Effect of oral D-penicillamine in Urinary excretion of lead.
- Author:
Chung Yill PARK
- Publication Type:Original Article
- MeSH:
Diagnosis;
Lead Poisoning;
Penicillamine*
- From:Korean Journal of Preventive Medicine
1976;9(1):87-94
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In order to study the chelating action of d-penicillamine on lead and the possibility of its application to the provocation test for diagnosis of lead poisoning, urinary excretion of lead was measured from 24-hour urine samples before, during and after administration of d-penicillamine by oral route for 5 days on 18 lead workers. The results were as follows: 1. Oral d-penicillamine 600 mg/day raised the excretion of urinary lead by approximately 3 times as compared with initial urinary lead level. 2. Initial urinary lead level was the better indicator of urinary lead excretion in d-penicillamine administration than initial blood lead delta-ALA and hemoglobin level. 3. Oral d-penicillamine may be quite useful in provocation test for lead poisoning.
