CTX-M-55-Type Extended-Spectrum beta-lactamase-Producing Shigella sonnei Isolated from a Korean Patient Who Had Travelled to China.
10.3343/alm.2013.33.2.141
- Author:
Wonmok LEE
1
;
Hae Sun CHUNG
;
Hyukmin LEE
;
Jong Hwa YUM
;
Dongeun YONG
;
Seok Hoon JEONG
;
Kyungwon LEE
;
Yunsop CHONG
Author Information
1. Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea. leekcp@yuhs.ac
- Publication Type:Case Reports
- Keywords:
CTX-M-55;
Shigella sonnei;
ESBL
- MeSH:
Adult;
Anti-Bacterial Agents/pharmacology;
Asian Continental Ancestry Group;
Cefotaxime/pharmacology;
China;
Drug Resistance, Bacterial/drug effects;
Dysentery, Bacillary/diagnosis/*microbiology;
Electrophoresis, Gel, Pulsed-Field;
Escherichia coli/metabolism;
Feces/microbiology;
Female;
Humans;
Plasmids/chemistry/genetics;
Republic of Korea;
Shigella sonnei/enzymology/*isolation & purification;
Travel;
beta-Lactamases/genetics/*metabolism
- From:Annals of Laboratory Medicine
2013;33(2):141-144
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of CTX-M-55-type extended-spectrum beta-lactamase (ESBL)-producing Shigella sonnei infection in a 27-year-old Korean woman who had traveled to China. The patient was admitted to the hospital due to abdominal pain, watery diarrhea, and fever (39.3degrees C). S. sonnei was isolated from her stool specimens, and the pathogen was found to be resistant to cefotaxime due to CTX-M-55-type ESBL. Insertion sequence (IS)Ecp1 was found upstream of the blaCTX-M-55 gene. The blaCTX-M-55 gene was transferred from the S. sonnei isolate to an Escherichia coli J53 recipient by conjugation. Pulsed-field gel electrophoresis and Southern blotting revealed that the blaCTX-M-55 gene was located on a plasmid of approximately 130 kb.
