An Experimental Study on the Vasopressor Effects of Various Sympathomimetic Amines in Reserpinized Dogs during N₂O-O₂-Halothane Anesthesia.
10.4097/kjae.1972.5.2.113
- Author:
Kwang Woo KIM
1
;
Kwang II SHIN
;
Soo Hong CHOI
;
Yong Lack KIM
;
II Young KWAK
Author Information
1. Department of Anesthesiology, Seoul National University, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Anesthesia*;
Animals;
Arterial Pressure;
Dogs*;
Ephedrine;
Epinephrine;
Mephentermine;
Methoxamine;
Norepinephrine;
Phenylephrine;
Sympathomimetics*
- From:Korean Journal of Anesthesiology
1972;5(2):113-120
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vasopressor effects of epinephrine, norepinephrine, ephedrine, phenylephrine, methoxamine and of mephentermine were compared in resrpinized dogs with or without nitrous oxide-oxygen-halothane anesthesia. The results are as follows: (1) Epinephrine and norepinephrine were shown to have the most potent pressor effect in reserpinized and nitrous oxide-oxygen-halothane-anesthetized dogs. Phenylephrine, methoxamine, mephen-termine and ephedrine were less potent in decreasing order. (2) Decrease in mean arterial pressure was less marked in dogs reserpinized and anesthetized with nitrous oxide-oxygen-halothane than in reserpinized but unanesthetized dogs. (3) It revealed that nitrous oxide-oxygen-halothane anesthesia potentiated the vasopressor effects of the sympathomimetic amines studied. Nitrous oxide-oxygen-halothane anesthesia is implicated to exert an sympathomimetic effect.
