Primary Biliary Cirrhosis-Autoimmune Hepatitis Overlap Syndrome.
- Author:
Jong Yup BAE
;
Young Nyun PARK
;
Chanil PARK
- Publication Type:Original Article
- Keywords:
Overlap syndrome;
Primary biliary cirrhosis;
Autoimmune hepatitis
- MeSH:
Alkaline Phosphatase;
Antibodies, Antinuclear;
Bile Ducts;
Biopsy;
Cholangitis;
Cholestasis;
Female;
Granuloma;
Hepatitis*;
Hepatitis, Autoimmune;
Hepatitis, Chronic;
Humans;
Immunoglobulin G;
Immunoglobulin M;
Liver;
Liver Cirrhosis, Biliary;
Middle Aged;
Necrosis
- From:Korean Journal of Pathology
1997;31(1):87-90
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cases sharing features of both primary biliary cirrhosis and autoimmune hepatitis have been reported as a mixed type, overlap syndrome, immunocholangitis and autoimmune cholangiopathy. A primary biliary cirrhosis- autoimmune hepatitis overlap syndrome is unusual and characterized by overlapping features; cholestasis, high titer of alkaline phosphatase, bile duct damage and granulomas in the liver biopsy, high antinuclear antibody, increased IgG and IgM and intra-acinar hepatitis with piecemeal necrosis. Autoimmune mechanisms are thought to play a major role in the pathogenesis of the overlapping syndrome and the bases of immunosuppressive therapy. A 58-year-old female patient shows overlapping clinical and laboratory findings, chronic active hepatitis in initial liver biopsy which transits to primary biliary cirrhosis with cholangitis and granulomas. This is a case of hepatobiliary lesion showing overlapping features of both primary biliary cirrhosis and autoimmune hepatitis over 3-year period.
