Apolipoprotein B-100/Apolipoprotein A-I Ratio is on Useful Indicator for Coronary Artery Disease in Koreans.
10.4070/kcj.2002.32.7.556
- Author:
Hyung Kwan KIM
1
;
Hyo Soo KIM
;
Seil OH
;
In Ho CHAE
;
Lang A KIM
;
Eue Keun CHOI
;
Kyung Woo PARK
;
Hyun Jai CHO
;
Cheol Ho KIM
;
Dae Won SOHN
;
Byung Hee OH
;
Myoung Mook LEE
;
Young Bae PARK
;
Yun Shik CHOI
Author Information
1. Department of Heart Research Institute, Seoul National University Medical Research Institute, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Apolipoproteins;
Coronary disease
- MeSH:
Apolipoprotein A-I;
Apolipoprotein B-100;
Apolipoproteins B;
Apolipoproteins*;
Cholesterol;
Constriction, Pathologic;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Disease;
Coronary Vessels*;
Diabetes Mellitus;
Female;
Humans;
Hypertension;
Lipoproteins;
Male;
Myocardial Infarction;
Triglycerides
- From:Korean Circulation Journal
2002;32(7):556-565
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Little is known about the relationship between the apolipoprotein (apo) B-100, or the apo B-100/apo A-I ratio, and coronary artery disease (CAD). The aim of this study was to investigate this association. SUBJECTS AND METHODS: Our study was carried out on 194 patients who had undergone elective coronary angiography (CAG), but had received no lipid-lowering medication. Patients with acute myocardial infarction were excluded. Stenosis of >or=50% in 1 or more coronary arteries was classified as CAD (+). RESULTS: HDL-C and apo A-I were significantly higher in females than in males (p=0.009 and 0.036). In our population we found that the apo A-I, HDL-C and the apo B-100/apo A-I ratio were significantly related to CAD (p=0.001, 0.006, and 0.007 respectively). In the male group (n=111), the apo B-100/apo A-I ratio was the only parameter statistically significant to CAD after correcting for age, diabetes mellitus and hypertension. Whereas, in the female group (n=83), the apo B/apo A-I ratio, apo B-100/apo A-I ratio, apo B-100, nonHDL-C, triglyceride, apo B, total cholesterol and low-density lipoprotein cholesterol were all significantly related to CAD (p=0.002, 0.003, 0.003, 0.007, 0.007, 0.009, 0.012 and 0.012 respectively). Of these parameters only the apo B-100/apo A-I ratio was significantly related to CAD in both female and male group. CONCLUSION: The apo B-100/apo A-I ratio is an useful indicator for discriminating between CAD (+) and CAD (-).
