Insulin Sensitivity is Associated with the Presence and Extent of Coronary Artery Disease.
10.4070/kcj.2002.32.7.566
- Author:
Ki Hwan KWON
1
;
Dong Hoon CHOI
;
Bon Kwon KOO
;
Young Guk KO
;
Young Sup BYUN
;
Sung Jin OH
;
Pil Ki MIN
;
Jae Hun JUNG
;
Yang Soo JANG
;
Won Heum SHIM
;
Seung Yun CHO
Author Information
1. Cardiovascular Division, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Insulin resistance;
Coronary angiography;
Coronary arteriosclerosis
- MeSH:
Angina Pectoris;
Arteriosclerosis;
Cholesterol, HDL;
Constriction, Pathologic;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels*;
Diabetes Mellitus;
Humans;
Insulin Resistance*;
Insulin*;
Male;
Multivariate Analysis;
Risk Factors
- From:Korean Circulation Journal
2002;32(7):566-572
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Insulin resistance has been suggested to be an important risk factor in the development of arteriosclerosis. The correlation between insulin sensitivity and the degree of coronary atherosclerosis in patients with angina pectoris was investigated. SUBJECTS AND METHODS: The study population consisted of 74 subjects with angina (54 men, 20 women), aged from 31 to 73 years. Coronary angiograms were evaluated by 3 semiquantitative scoring systems (vessel score, stenosis score and extent score) to estimate the extent of focal and diffuse coronary artery disease (CAD). Insulin sensitivity (K ITT) was determined by an insulin tolerance test. RESULTS: There were significant correlations between K ITT and all 3 coronary scores. Multivariate analysis revealed significant and independent correlations between all 3 coronary scores and K ITT , even in patients without diabetes mellitus. Both HDL cholesterol level and K ITT were significantly lower in patients with CAD than in those without. CONCLUSION: Decreased insulin sensitivity was significantly associated with the presence and extent of CAD. These results suggest the potential benefits of insulin-sensitizing treatment strategies for patients with decreased insulin sensitivity.
