Gastrointestinal Risk Factors and Non-steroidal Anti-inflammatory Drugs Use in Rheumatoid Arthritis and Osteoarthritis Patients in Korea.
- Author:
Eun Young LEE
1
;
Seung Jae HONG
;
Yong Beom PARK
;
Kyung Su PARK
;
Chan Bum CHOI
;
Chang Keun LEE
;
Ran SONG
;
Yun Jong LEE
;
Chang Hee SUH
;
Hyun Ah KIM
;
Jun Ki MIN
;
Chong Hyeon YOON
;
Won PARK
;
Won Tae CHUNG
;
Geun Tae KIM
;
Jung Yoon CHOE
;
Seong Wook KANG
;
Yong Wook PARK
;
Wan Hee YOO
;
Sang Heon LEE
Author Information
- Publication Type:Original Article
- Keywords: Rheumatoid arthritis; Osteoarthritis; Gastrointestinal risk factors; Non-steroidal anti-inflammatory agents
- MeSH: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Arthritis; Arthritis, Rheumatoid*; Aspirin; Comorbidity; Cyclooxygenase 2 Inhibitors; Glucocorticoids; Helicobacter pylori; Hospitals, University; Humans; Korea*; Medical Records; Observational Study; Osteoarthritis*; Prostaglandin-Endoperoxide Synthases; Risk Factors*; Smoke; Smoking
- From:Journal of Rheumatic Diseases 2016;23(1):47-54
- CountryRepublic of Korea
- Language:Korean
- Abstract: OBJECTIVE: The aim of this study was to examine and compare the gastrointestinal (GI) risk factors and treatment patterns of rheumatoid arthritis (RA) and osteoarthritis (OA) patients in Korea. METHODS: This was a cross-sectional, observational study on RA and OA patients taking non-steroidal anti-inflammatory drugs (NSAIDs) for at least 1 month. A total of 1,896 patients (981 RA patients, 915 OA patients) were recruited from 20 university hospitals. Data were collected through medical records and patient surveys. GI risk factors included age, prolonged (over 3 months) or high-dose use of NSAIDs, alcohol drinking, smoking, use of aspirin, anticoagulants or glucocorticoids, comorbidities, and history of Helicobacter pylori infection or other GI complications. Treatment patterns were classified according to groups using, selective cyclooxygenase (COX)-2 inhibitors+/-gastro-protective agents, non-selective COX-2 inhibitors+proton pump inhibitor, or non-selective COX-2 inhibitors+/-other gastro-protective agents. RESULTS: GI risk factors were highly present in both RA and OA patients. The proportion of prolonged use of NSAIDs, smoking, and glucocorticoid use were higher in RA patients (p<0.001). The proportion of comorbidities and use of aspirin were higher in OA patients (p<0.001). The remaining GI risk factors were present in similar proportions in both groups. Use of selective COX-2 inhibitors or gastro-protective agents was higher in RA patients. CONCLUSION: Prolonged use of NSAIDs and concomitant glucocorticoid use were higher in RA patients, while comorbidities and concomitant aspirin use were predominant in OA patients. These results will provide insights for use in development of future guidelines for proper selection of NSAIDs and effective prevention of GI complications in arthritis patients.
