Effect of Hypoxia and Reoxygenation on Cultured Human Dermal Fetal Fibroblast.
- Author:
Beyoung Yun PARK
1
;
Jong Woo CHOI
;
Hyug Jun KWARK
;
Won Jai LEE
;
Dong Kyun RAH
Author Information
1. Institue for Human Tissue Restoration, Department of Plastic & Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea. dkrah@ yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Hypoxia;
Re-oxygenation;
Fetal fibroblast;
Collagen;
TGF-beta;
VEGF
- MeSH:
Adult;
Anoxia*;
Collagen;
Fibroblasts*;
Humans*;
Oxygen;
Transforming Growth Factor beta;
Vascular Endothelial Growth Factor A;
Wound Healing
- From:Journal of the Korean Society of Plastic and Reconstructive Surgeons
2005;32(3):347-356
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In control group, fetal and adult fibroblasts were cultured under normoxic condition. The experimental groups were allocated into four different groups. The differences in TGF-beta, VEGF under 24, 48, 72 hours were statistically investigated. Compared to adult fibroblast group, there was a statistically significant increase (p<0.01) in the rates of protein synthesis in TGF-beta and VEGF of fetal fibroblast. In this study, these results may reflect the possibility that fetal fibroblast are more susceptible to change in oxygen and has a superior rate of angiogenesis through increased VEGF expression. The possible superiority of angiogenesis in fetal fibroblast may play an important role in scarless wound healing.
