Efficacy and Safety of Dexmedetomidine for Postoperative Delirium in Adult Cardiac Surgery on Cardiopulmonary Bypass.
- Author:
Jae Bum PARK
1
;
Seung Ho BANG
;
Hyun Keun CHEE
;
Jun Seok KIM
;
Song Am LEE
;
Je Kyoun SHIN
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Korea. drjsk@kuh.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Postoperative care;
Dexmedetomidine;
Complication;
Thoracic surgery
- MeSH:
Adult*;
Cardiopulmonary Bypass*;
Delirium*;
Dexmedetomidine*;
Hemodynamics;
Humans;
Incidence;
Critical Care;
Length of Stay;
Postoperative Care;
Postoperative Complications;
Prevalence;
Thoracic Surgery*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2014;47(3):249-254
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Delirium after cardiac surgery is associated with serious long-term negative outcomes and high costs. The aim of this study is to evaluate neurobehavioral, hemodynamic, and sedative characteristics of dexmedetomidine, compared with the current postoperative sedative protocol (remifentanil) in patients undergoing open heart surgery with cardiopulmonary bypass (CPB). METHODS: One hundred and forty two eligible patients who underwent cardiac surgery on CPB between April 2012 and March 2013 were randomly divided into two groups. Patients received either dexmedetomidine (range, 0.2 to 0.8 microg/kg/hr; n=67) or remifentanil (range, 1,000 to 2,500 microg/hr, n=75). The primary end point was the prevalence of delirium estimated daily via the confusion assessment method for intensive care. RESULTS: When the delirium incidence was compared with the dexmedetomidine group (6 of 67 patients, 8.96%) and the remifentanil group (17 of 75 patients, 22.67%) it was found to be significantly less in the dexmedetomidine group (p<0.05). There were no statistically significant differences between two groups in the extubation time, ICU stay, total hospital stay, and other postoperative complications including hemodynamic side effects. CONCLUSION: This preliminary study suggests that dexmedetomidine as a postoperative sedative agent is associated with significantly lower rates of delirium after cardiac surgery.
