A Case of Xanthoma Disseminatum with Diabetes Insipidus.
- Author:
Kyu Won CHOI
1
;
Chae Young LEE
;
Yeong Kyu LEE
;
Hong Seok KIM
;
Chae Wook LEE
;
Ki Ho KIM
;
Young Hun KIM
Author Information
1. Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea. mucca@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Diabetes insipidus;
Xanthoma disseminatum
- MeSH:
Axis, Cervical Vertebra;
Cyclophosphamide;
Diabetes Insipidus;
Eyelids;
Histiocytosis;
Histiocytosis, Non-Langerhans-Cell;
Humans;
Lasers, Gas;
Male;
Volatilization;
Xanthomatosis
- From:Korean Journal of Dermatology
2008;46(6):826-830
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Xanthoma disseminatum (XD) is a rare, potentially progressive non-Langerhans cell histiocytosis, which preferentially affects males in their childhood or young adulthood. It is characterized by the insidious onset of small, yellowish-red to brown papules and nodules that are discrete and disseminated. They characteristically involve the eyelids and flexural areas of the axillary and inguinal folds, and the antecubital and popliteal fossae. Systemic disease frequently occurs, the most common manifestation being diabetes insipidus (DI), which occurs in about 40% of cases and is due to deposition of xanthoma cells in the hypothalamic-pituitary axis. We present a case of XD with DI, which was treated with the combination therapy of CO2 laser vaporization, cyclophosphamide, electrocauterization and synthetic anti-diuretic hormone.
