Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease.
10.14405/kjvr.2016.56.4.205
- Author:
Kyu Tae KIM
1
;
Hee Myung PARK
;
Changbaig HYUN
;
Kyoung Won SEO
;
Kun Ho SONG
Author Information
1. College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea. songkh@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
5-HT concentration;
body condition score;
dogs;
myxomatous mitral valve disease;
obesity
- From:Korean Journal of Veterinary Research
2016;56(4):205-208
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of the present study is to investigate the potential influence of obesity as a factor in 5-hydroxytryptamine (5-HT) concentration in myxomatous mitral valve disease (MMVD) dogs. Fifty-five client-owned dogs were enrolled in a randomized trial. Dogs were classified by echocardiography into healthy (control), mild, and moderate to severe MMVD groups. Each group was subclassified by using a 9-point body condition score (BCS); lean (BCS 5–6/9) and obese groups (BCS 7.5–9/9). Dogs with moderate to severe MMVD had lower serotonin (5-HT) concentrations than the control group (p = 0.03). Dogs with moderate to severe MMVD (p = 0.017) had lower serum 5-HT concentrations than the control group in the obese group (BCS 7.5–9/9). Significant difference was found between the lean and obese groups (p = 0.015) which are not consider severe in the MMVD group. These results suggested that 5-HT concentration was decreased with the increasing severity of MMVD, and obesity might be taken into consideration when interpreting the serotonin concentration in MMVD dogs.
