Evaluation of plasma N-terminal pro-brain natriuretic peptide and troponin I concentrations in dogs with congenital ventricular outflow tract stenosis.
10.14405/kjvr.2016.56.4.223
- Author:
Gye Dong KIM
1
;
Sang IL SUH
;
In Chul PARK
;
Changbaig HYUN
Author Information
1. Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea. hyun5188@kangwon.ac.kr
- Publication Type:Original Article
- Keywords:
aortic valve stenosis;
pressure gradient;
pro-brain natriuretic peptide (1-76);
pulmonary valve stenosis;
troponin I
- From:Korean Journal of Veterinary Research
2016;56(4):223-227
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study evaluated the levels of cardiac biomarkers in dogs with either pulmonic stenosis or aortic stenosis and the correlation between biomarkers and the severity of stenosis assessed by the echocardiography. To achieve this study goal, 38 dogs (10 healthy control dogs, 15 dogs with pulmonic stenosis and 13 dogs with aortic stenosis) were examined. The jet velocity and pressure gradient in this study population were measured by echocardiographic estimation, after which the study group was subdivided by the severity of stenosis. The plasma cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured in this study group. The median concentrations of cTnI and NT-proBNP of the disease group were significantly higher than those of the control group, and these increased gradually as stenosis worsened. The severity of stenosis and the concentrations of cTnI and NT-porBNP were also found to be significantly correlated. Finally, the plasma cTnI and NT-proBNP tests were found to beneficial for differentiating clinical patients, predicting the progression of disease, and monitoring the outcome of interventional therapy for stenosis.
