Hangover relieving effect of Sanghwang mushroom mycelium extract.
10.14405/kjvr.2016.56.4.241
- Author:
Min Su KIM
1
;
Yoo Jin AN
;
Jae Chul LEE
;
Ga Ryoung PARK
;
Dong Soo PARK
;
Nam Gen JEON
;
Youngjae LEE
;
Chang Hoon HAN
Author Information
1. College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea. chhan@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
blood aldehyde concentration;
hangover relieving effect;
locomotor activity test;
Sanghwang mushroom mycelium extract
- From:Korean Journal of Veterinary Research
2016;56(4):241-247
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was conducted to evaluate the hangover relieving effect of Sanghwang mushroom mycelium extract (SME). The extract showed 1,1-diphenyl-2-picrylhydrazyl radical scavenging effect in a concentration-dependent manner and high antioxidant capacity (56.67 ± 1.77%) when administered at 120 µg/mL. In addition, SME significantly increased (p < 0.005) the aldehyde dehydronase (ALDH) activity (126.03 ± 9.11%) when applied at 8 or 16 µL/mL. A locomotor activity test showed that the alcohol-water treated group showed significantly decreased motor activity at 90 min post-administration. However, the alcohol-SME treated group showed a 20-fold higher motor activity than that observed in the alcohol-water treated group at 90 min post-administration. Blood was harvested from each mouse at 90 min post-administration, and both alcohol and aldehyde concentrations were measured. The alcohol-SME treated group showed significantly lower (p < 0.5) alcohol (120.13 ± 12.83 µg/mL) and aldehyde (7.26 ± 1.22 µg/mL) concentrations than the values observed in the alcohol-water treated group. These results suggest that the hangover relieving effect of SME results from increased ALDH activity, which reduces the aldehyde concentration in the blood.
