Assessment of Serum Ferritin Levels in Plateletpheresis Donors.
10.17945/kjbt.2015.26.3.282
- Author:
Jaehyun KIM
1
;
Kyoung Young CHOI
;
Jin Hyuk YANG
;
So Yong KWON
;
Deok Ja OH
Author Information
1. Blood Transfusion Research Institute, Korean Red Cross, Wonju, Korea. dj57_2000@redcross.or.kr
- Publication Type:Original Article
- Keywords:
Blood donors;
Plateletpheresis;
Iron-Deficiency anemia;
Ferritin
- MeSH:
Anemia, Iron-Deficiency;
Blood Donors;
Donor Selection;
Erythrocytes;
Female;
Ferritins*;
Humans;
Iron;
Male;
Mass Screening;
Plateletpheresis*;
Tissue Donors*
- From:Korean Journal of Blood Transfusion
2015;26(3):282-290
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: While plateletpheresis donation results in less red blood cell loss and therefore less depletion of storage iron, repeated plateletpheresis can also lead to iron depletion. To determine the safety of regular plateletpheresis donations, this study estimated donor's iron status according to age, gender, number of donations, and donation interval. METHODS: The study population included 5,109 plateletpheresis donors (4,824 males, 285 females), who passed the hemoglobin (Hb) criteria for plateletpheresis donation of 12.0 g/dL or more in an inclusion period (September 2013~November 2013). During donor screening, serum ferritin levels were measured for assessment of iron status of plateletpheresis donors. RESULTS: Mean age of donors was 30.4 years (range: 17~59). Donors with a history of donation of more than 3 years accounted for 89.3% and 74.0% in males and females, respectively. Mean donation interval and annual donation number in male (female) donors was 11.9 (7.2) weeks and 4.2 (8.7) times, respectively. Approximately 37.8% of male donors and 64.2% of female donors had a serum ferritin level of less than 15 ng/mL. Serum ferritin levels showed correlation with donation interval, as the percentage of donors with a low ferritin level decreased with increase in donation interval (rho: 0.191~0.438, P<0.001). Serum ferritin levels also showed correlation with annual plateletpheresis number (rho: -0.261~-0.411, P<0.001). CONCLUSION: Depleted iron store was observed in nearly 40% of donors who had acceptable Hb levels for plateletpheresis donation. Hb pre-donation screening is not sufficient to reduce the risk of iron deficiency in regular plateletpheresis donors.
