Korean Red Cross HLA-Matched Platelet Donor Registry.
10.17945/kjbt.2015.26.3.291
- Author:
So Yong KWON
1
;
Sun Ah LEE
;
A Hyun LIM
;
Nam Sun CHO
;
Cheol Ho JUNG
;
Jin Hyuk YANG
;
Kyoung Un PARK
Author Information
1. Seoul Nambu Blood Center, Korean Red Cross, Seoul, Korea. sykwon@redcross.or.kr
- Publication Type:Original Article
- Keywords:
HLA-matched platelet;
Donor registry;
Platelet refractoriness
- MeSH:
Blood Platelets*;
HLA-A Antigens;
HLA-B Antigens;
Humans;
Platelet Transfusion;
Plateletpheresis;
Red Cross*;
Tissue Donors*
- From:Korean Journal of Blood Transfusion
2015;26(3):291-299
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Transfusion of HLA-matched platelets is required when development of platelet refractoriness occurs after repeated platelet transfusion. This study was conducted to establish a HLA-matched platelet donor registry to supply matched platelets to patients who develop platelet refractoriness. METHODS: HLA-matched platelet donors were recruited among plateletpheresis donors. HLA-A and HLA-B antigen types of recruited donors were tested using a polymerase chain reaction-sequence specific oligonucleotide probe method. RESULTS: A total of 1,029 plateletpheresis donors were recruited. HLA-A and HLA-B antigen frequencies of recruited donors were similar to those of previously reported HLA antigen frequencies of Koreans. During the study period, a patient with platelet refractoriness recovered after receiving six units of HLA-matched platelets. CONCLUSION: During this study 1,029 donors were registered as HLA-matched platelet donors and a patient with platelet refractoriness received HLA-matched platelets using this registry. Supply of HLA-matched platelets will be facilitated by continuous expansion of the number of registered HLA-matched platelet donors, development of a program for management and searching for HLA-matched donors, and establishment of a request-supply system between hospitals and the Korean Red Cross through further studies.
