A Case Report of Transfusion-Related Acute Lung Injury Induced in the Patient with HLA Antibody after Fresh Frozen Plasma Transfusion.
10.17945/kjbt.2015.26.3.309
- Author:
Ki Sul CHANG
1
;
Dae Won JUN
;
Youngil KIM
;
Hyunwoo OH
;
Min Koo KANG
;
Junghoon LEE
;
Intae MOON
Author Information
1. Department of Internal Medicine, Hanyang University Seoul Hospital, Seoul, Korea. noshin@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Transfusion-related acute lung injury (TRALI);
Fresh frozen plasma (FFP);
Anti-HLA antibody
- MeSH:
Acute Lung Injury*;
Anoxia;
Antibodies;
Blood Transfusion;
Catheters;
Cholecystitis;
Cyanosis;
Hemoptysis;
Humans;
Leukocytes;
Liver Cirrhosis;
Male;
Mortality;
Oxygen;
Plasma*;
Pulmonary Edema;
Tachycardia;
Tachypnea;
Thorax
- From:Korean Journal of Blood Transfusion
2015;26(3):309-315
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Development of transfusion-related acute lung injury (TRALI), a non-cardiogenic pulmonary edema, after blood transfusion, is a rare but potentially leading cause of mortality from blood transfusion. We report on a case of TRALI in a 51-year male with acute calculous cholecystitis and liver cirrhosis. As preoperative treatment, he was given ten units of fresh frozen plasma (FFP) for 3 days before the operation. During the transfusion of the 10th unit of FFP, he experienced a sudden onset of hemoptysis, tachypnea, tachycardia, and cyanosis. Bilateral pulmonary infiltration not observed on the chest X-ray at the visit was newly developed. There was no evidence of volume overload but severe hypoxemia. Blood transfusion was stopped and he recovered fully after 8 days of oxygen therapy through a nasal cannula. Although HLA and HNA antibodies were not detected in the donor's blood, HLA antibodies (A2, B57, B58) were detected in the patient's blood. We reported this meaningful case of TRALI that occurred after transfusion of only fresh frozen plasma which did not contain human leukocyte antibody in a patient with HLA antibody.
