A Case of Washed Platelet Transfusion in a Patient with History of Recurrent Transfusion Reaction.
10.17945/kjbt.2015.26.3.316
- Author:
Ji Yeon SOHN
1
;
Joo Hyoung HWANG
;
Hyang Lae LEE
;
Hye Lim YI
;
Su Jin KANG
;
Hyeon Seok EOM
;
Eun Kyung LEE
;
Sinyoung KIM
;
Kyoung Un PARK
;
Sun Young KONG
Author Information
1. Department of Laboratory Medicine, Center for Diagnostic Oncology, Hospital, National Cancer Center, Goyang, Korea. ksy@ncc.re.kr
- Publication Type:Case Report
- Keywords:
Washed platelet;
Transfusion reaction;
Anaphylaxis
- MeSH:
Abdominal Pain;
Anaphylaxis;
Blood Component Removal;
Blood Group Incompatibility*;
Blood Platelets*;
Drug Therapy;
Haptoglobins;
Hematopoietic Stem Cell Transplantation;
Hemolysis;
Humans;
Hydrocortisone;
Immunoglobulin A;
Lymphoma, T-Cell;
Male;
Oximetry;
Oxygen;
Platelet Count;
Platelet Transfusion*;
Sweat;
Sweating;
Thorax;
Vision Disorders
- From:Korean Journal of Blood Transfusion
2015;26(3):316-322
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anaphylactic transfusion reaction is caused by deficiency of certain protein(s) in the recipient. We report on the experience of platelet count recovery using washed platelets for transfusion in a patient who developed an anaphylactic transfusion reaction. A 50-year old male diagnosed with angioimmunoblastic T-cell lymphoma was treated with chemotherapy followed by autologous hematopoietic stem cell transplantation. Immediately after starting transfusion of apheresis platelets, he began sweating and complained of visual impairment, chest discomfort, and abdominal pain. Both systolic and diastolic blood pressures and oxygen saturation monitored by pulse oximetry were decreased. Platelet transfusion was discontinued immediately and hydrocortisone was administered, and the symptoms and signs were resolved within two hours. Laboratory test using post-transfusion blood showed no apparent evidence of hemolysis. Platelet washing procedure using normal saline three times was newly set to prevent anaphylactic reaction in the patient. Transfusions of washed platelets were performed 20 times for 60 days, and the patient showed no anaphylactic reaction during this period. He showed no evidence of immunoglobulin A, haptoglobin, C3, or C4 deficiencies. We confirmed that washed platelet transfusion is highly effective for prevention of anaphylactic transfusion reaction.
